PDD0002 - Enzyme Kinetics

Course Description

Drug development is a long and expensive process that starts with the identification of a hit compound endowed that hinders the development of a given disease and proceeds through subsequent rounds of structural changes and optimization until the desired pharmacological properties are reached (lead compound. The precise mechanism of action studies, as well as quantitative measurement of the performance of the compound against its target, requires Enzyme Kinetic and therefore essential component of the drug development process. F. Peter Guengerich, the Tadashi Inagami Professor of Biochemistry at Vanderbilt University School of Medicine and the Associate Editor for The Journal of Biological Chemistry since 2006, will introduce concepts of Enzyme Kinetics, a central component to understanding pharmacology and drug discovery. The overall course objectives include topics like the mechanism of drug actions, inhibitors, key parameters for measuring the efficiency of action, how enzyme metabolism can make drugs more toxic, and the application of these concepts in drug distribution, absorption, bioavailability, and multiple dosing. Overall this course will provide an introduction to enzyme kinetics as a key component of drug discovery.